Sanguinarine Interacts with Chromatin, Modulates Epigenetic Modifications, and Transcription in the Context of Chromatin
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چکیده
منابع مشابه
Sanguinarine, Putative Anticancer Therapeutic, Interacts with Chromatin, Modulates Epigenetic Modifications and Transcription in Context of Chromatin
Preparation of Chromatin and Mononucleosome from Rat Liver Purified nuclei were digested with micrococcal nuclease for the preparation of chromatin. Prolonged digestion of the nuclei with micrococcal nuclease was used to prepare mononucleosome with a DNA length of 146 base pairs. Selective solubilization of mononucleosome was done by the acidification (NaH2PO4 1.78% w/v) of the supernatant. The...
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The mammalian genome is organized into silenced and active domains, which are constituted by chromatin fibres. The fibres are comprised of nucleosome subunits in which nearly two turns of DNA wrap around a histone protein core. This first order of DNA structure is known as the 10 nm chromatin fibre. Almost since the discovery of the nucleosome our widely accepted paradigm of genome regulation h...
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The human ISWI-containing factor RSF (remodeling and spacing factor) was found to mediate nucleosome deposition and, in the presence of ATP, generate regularly spaced nucleosome arrays. Using this system, recombinant chromatin was reconstituted with bacterially produced histones. Acetylation of the histone tails was found to play an important role in establishing regularly spaced nucleosome arr...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2009
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2008.12.006